Captopril suppression test

Captopril suppression test

In medicine, the captopril suppression test, also CST, is a non-invasive test used to help diagnose primary aldosteronism ("Conn syndrome"). It should not be confused with the "captopril challenge test".

In the "captopril suppression test" the plasma aldosterone is measured.cite journal |author=Agharazii M, Douville P, Grose JH, Lebel M |title=Captopril suppression versus salt loading in confirming primary aldosteronism |journal=Hypertension |volume=37 |issue=6 |pages=1440–3 |year=2001 |month=June |pmid=11408392 |doi= |url=http://hyper.ahajournals.org/cgi/pmidlookup?view=long&pmid=11408392] In normal individuals aldosterone is suppressed by captopril, via the renin-angiotensin-aldosterone system.

Relation to "captopril challenge test"

The CST should not be confused with the "captopril challenge test", [cite journal |author=Racine MC, Douville P, Lebel M |title=Functional tests for primary aldosteronism: value of captopril suppression |journal=Curr. Hypertens. Rep. |volume=4 |issue=3 |pages=245–9 |year=2002 |month=June |pmid=12003708 |doi= |url=] a test used to diagnose renal artery stenosis.

The "challenge" test looks for a problem with the renal artery (stenosis). The "suppression" test looks for a problem related to the adrenal gland (over production of a mineralocorticoids).

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