GABRA3

GABRA3

Gamma-aminobutyric acid (GABA) A receptor, alpha 3, also known as GABRA3, is a human gene.cite web | title = Entrez Gene: GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2556| accessdate = ]

PBB_Summary
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summary_text = GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identifiedcite web | title = Entrez Gene: GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2556| accessdate = ]

ee also

* GABAA receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Buckle VJ, Fujita N, Ryder-Cook AS, "et al." |title=Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease. |journal=Neuron |volume=3 |issue= 5 |pages= 647–54 |year= 1990 |pmid= 2561974 |doi=
*cite journal | author=Bell MV, Bloomfield J, McKinley M, "et al." |title=Physical linkage of a GABAA receptor subunit gene to the DXS374 locus in human Xq28. |journal=Am. J. Hum. Genet. |volume=45 |issue= 6 |pages= 883–8 |year= 1990 |pmid= 2574000 |doi=
*cite journal | author=Tögel M, Mossier B, Fuchs K, Sieghart W |title=gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12993–8 |year= 1994 |pmid= 8175718 |doi=
*cite journal | author=Hadingham KL, Wingrove P, Le Bourdelles B, "et al." |title=Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors. |journal=Mol. Pharmacol. |volume=43 |issue= 6 |pages= 970–5 |year= 1993 |pmid= 8391122 |doi=
*cite journal | author=Belelli D, Lambert JJ, Peters JA, "et al." |title=The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 20 |pages= 11031–6 |year= 1997 |pmid= 9380754 |doi=
*cite journal | author=Huang RQ, Dillon GH |title=Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin. |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 243–55 |year= 1998 |pmid= 9655866 |doi=
*cite journal | author=Amir R, Dahle EJ, Toriolo D, Zoghbi HY |title=Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq. |journal=Am. J. Med. Genet. |volume=90 |issue= 1 |pages= 69–71 |year= 2000 |pmid= 10602120 |doi=
*cite journal | author=Bedford FK, Kittler JT, Muller E, "et al." |title=GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. |journal=Nat. Neurosci. |volume=4 |issue= 9 |pages= 908–16 |year= 2001 |pmid= 11528422 |doi= 10.1038/nn0901-908
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chou KC |title=Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 3 |pages= 636–42 |year= 2004 |pmid= 15033447 |doi= 10.1016/j.bbrc.2004.02.098
*cite journal | author=Henkel V, Baghai TC, Eser D, "et al." |title=The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=126 |issue= 1 |pages= 82–7 |year= 2004 |pmid= 15048654 |doi= 10.1002/ajmg.b.20137
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

External links

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