DICER1

Dicer 1, ribonuclease type III
Identifiers
Symbols	DICER1; DCR1; Dicer; HERNA; KIAA0928
External IDs	OMIM: 606241 MGI: 2177178 HomoloGene: 13251 GeneCards: DICER1 Gene
EC number	3.1.26.-
Gene Ontology Molecular function • nucleotide binding • double-stranded RNA binding • helicase activity • endonuclease activity • ribonuclease III activity • ribonuclease III activity • protein binding • ATP binding • ATP-dependent helicase activity • hydrolase activity • metal ion binding Cellular component • intracellular • cytoplasm • cytosol • RNA-induced silencing complex Biological process • negative regulation of transcription from RNA polymerase II promoter • angiogenesis • RNA processing • negative regulation of Schwann cell proliferation • positive regulation of Schwann cell differentiation • stem cell maintenance • nerve development • lung development • production of siRNA involved in RNA interference • targeting of mRNA for destruction involved in RNA interference • gene silencing by RNA • pre-microRNA processing • positive regulation of myelination • peripheral nervous system myelin formation • embryonic hindlimb morphogenesis • production of miRNAs involved in gene silencing by miRNA • branching morphogenesis of a tube • neuron projection morphogenesis • cardiac muscle cell development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23405	192119
Ensembl	ENSG00000100697	ENSMUSG00000041415
UniProt	Q9UPY3	Q3UUV8
RefSeq (mRNA)	NM_001195573.1	NM_148948.2
RefSeq (protein)	NP_001182502.1	NP_683750.2
Location (UCSC)	Chr 14: 95.55 – 95.62 Mb	Chr 12: 105.93 – 105.99 Mb
PubMed search	[1]	[2]

Dicer1, Dcr-1 homolog (Drosophila), also known as DICER1, is a protein which in humans is encoded by the DICER1 gene.^[1][2] It is present in many organisms as Dicer.^[3]

Function

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and microRNA (a.k.a. small temporal RNA) pathways to produce the active small RNA component that represses gene expression. Two transcript variants encoding the same protein have been identified for this gene.^[1]

Clinical significance

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.^[4]

Interactions

DICER1 has been shown to interact with TARBP2^[5] and EIF2C2.^[6]

References

1. ^ ^{a b} "Entrez Gene: DICER1 Dicer1, Dcr-1 homolog (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23405. 
2. ^ Matsuda S, Ichigotani Y, Okuda T, Irimura T, Nakatsugawa S, Hamaguchi M (January 2000). "Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase". Biochim. Biophys. Acta 1490 (1–2): 163–9. PMID 10786632. 
3. ^ Jaskiewicz L, Filipowicz W (2008). "Role of Dicer in posttranscriptional RNA silencing". Curr. Top. Microbiol. Immunol. 320: 77–97. doi:10.1007/978-3-540-75157-1_4. PMID 18268840. 
4. ^ Kaneko H, Dridi S, Tarallo V, et al. (2011). "DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration". Nature 471 (7338): 325–330. doi:10.1038/nature09830. PMC 3077055. PMID 21297615. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3077055. 
5. ^ Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA, Rossi S, Fernandez AF, Carneiro F, Oliveira C, Ferreira B, Liu CG, Villanueva A, Capella G, Schwartz S, Shiekhattar R, Esteller M (March 2009). "A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function". Nat. Genet. 41 (3): 365–70. doi:10.1038/ng.317. PMID 19219043. 
6. ^ Doi, Noboru; Zenno Shuhei, Ueda Ryu, Ohki-Hamazaki Hiroko, Ui-Tei Kumiko, Saigo Kaoru (Jan. 2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors". Curr. Biol. (England) 13 (1): 41–6. doi:10.1016/S0960-9822(02)01394-5. ISSN 0960-9822. PMID 12526743. 

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954. 
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146. 
• Provost P, Samuelsson B, Rådmark O (1999). "Interaction of 5-lipoxygenase with cellular proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1881–5. doi:10.1073/pnas.96.5.1881. PMC 26705. PMID 10051563. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26705. 
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032. 
• Suk K, Kim S, Kim YH, et al. (2000). "Identification of a novel human member of the DEAD box protein family". Biochim. Biophys. Acta 1501 (1): 63–9. PMID 10727850. 
• Matsuda S, Ichigotani Y, Okuda T, et al. (2000). "Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase". Biochim. Biophys. Acta 1490 (1–2): 163–9. PMID 10786632. 
• Tabara H, Yigit E, Siomi H, Mello CC (2002). "The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans". Cell 109 (7): 861–71. doi:10.1016/S0092-8674(02)00793-6. PMID 12110183. 
• Provost P, Dishart D, Doucet J, et al. (2002). "Ribonuclease activity and RNA binding of recombinant human Dicer". EMBO J. 21 (21): 5864–74. doi:10.1093/emboj/cdf578. PMC 131075. PMID 12411504. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=131075. 
• Zhang H, Kolb FA, Brondani V, et al. (2002). "Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP". EMBO J. 21 (21): 5875–85. doi:10.1093/emboj/cdf582. PMC 131079. PMID 12411505. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=131079. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Doi N, Zenno S, Ueda R, et al. (2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors". Curr. Biol. 13 (1): 41–6. doi:10.1016/S0960-9822(02)01394-5. PMID 12526743. 
• Kawasaki H, Taira K (2003). "Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells". Nucleic Acids Res. 31 (2): 700–7. doi:10.1093/nar/gkg158. PMC 140522. PMID 12527779. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140522. 
• Kawasaki H, Suyama E, Iyo M, Taira K (2003). "siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells". Nucleic Acids Res. 31 (3): 981–7. doi:10.1093/nar/gkg184. PMC 149204. PMID 12560494. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149204. 
• Sasaki T, Shiohama A, Minoshima S, Shimizu N (2004). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857. 
• Handa V, Saha T, Usdin K (2003). "The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer". Nucleic Acids Res. 31 (21): 6243–8. doi:10.1093/nar/gkg818. PMC 275460. PMID 14576312. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=275460. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Tahbaz N, Kolb FA, Zhang H, et al. (2004). "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer". EMBO Rep. 5 (2): 189–94. doi:10.1038/sj.embor.7400070. PMC 1298981. PMID 14749716. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1298981. 
• Zhang H, Kolb FA, Jaskiewicz L, et al. (2004). "Single processing center models for human Dicer and bacterial RNase III". Cell 118 (1): 57–68. doi:10.1016/j.cell.2004.06.017. PMID 15242644. 

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