- Secretin receptor family
Pfam_box
Symbol = 7tm_2
Name = Secretin family of 7 transmembrane receptors
width =
caption =
Pfam= PF00002
InterPro= IPR000832
SMART=
PROSITE = PDOC00559
SCOP = 1bl1
TCDB =
OPM family = 6
OPM protein = 1fjr
PDB= PDB|1bl1 ; 17-30; PDB|1et2 S 184-46 PDB|1et3 S 184-46Secretin family of 7 transmembrane receptors is a family of evolutionarily related proteins.cite journal | author = Harmar AJ | title = Family-B G-protein-coupled receptors | journal = Genome Biol. | volume = 2 | issue = 12 | pages = REVIEWS3013 | year = 2001 | pmid = 11790261 | doi = 10.1186/gb-2001-2-12-reviews3013 | issn = ]
This family is known as Family B, the secretin-receptor family or family 2 of the
G-protein-coupled receptors .They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families (B1-B3) are recognized. Many secretin receptors are regulated bypeptide hormones from theglucagon hormone family .The secretin-like GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptides and
vasoactive intestinal peptide receptor s, all of which activateadenylyl cyclase and the phosphatidyl-inositol-calcium pathway. These receptors have 7 transmembrane helices, like rhodopsin-like GPCRs. However,there is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique '7TM' signature.Subfamily B1
Subfamily B1 contains classical
hormone receptor s, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways.*
Pituitary adenylate cyclase-activating polypeptide type 1 receptor InterPro|IPR002285
**PACR ;PACAPR
*Calcitonin receptor InterPro|IPR003287
**CALCR
*Corticotropin-releasing hormone receptor InterPro|IPR003051
**CRHR1 ;CRHR2
*Glucose-dependent insulinotropic polypeptide receptor/Gastric inhibitory polypeptide receptor InterPro|IPR001749
**GIPR
*Glucagon receptor-related InterPro|IPR003290
**GLP1R ;GLP2R ;
*Growth hormone releasing hormone receptor InterPro|IPR003288
**GHRHR
*Parathyroid hormone receptor InterPro|IPR002170
**PTHR1 ;PTHR2
*Secretin receptor InterPro|IPR002144
**SCTR
*Vasoactive intestinal peptide receptor InterPro|IPR001571
**VIPR1 ;VIPR2 Subfamily B2
Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen
CD97 ; calcium-independent receptors forlatrotoxin (such as UniProt|O94910, andbrain-specific angiogenesis inhibitor receptors (such as UniProt|O14514) amongst others.*
Brain-specific angiogenesis inhibitor InterPro|IPR008077
**BAI1 ;BAI2 ;BAI3
*CD97 antigen InterPro|IPR003056
**CD97
*EMR hormone receptor InterPro|IPR001740
**CELSR1 ;CELSR2 ;CELSR3 ;EMR1 ;EMR2 ;EMR3 ;EMR4
*GPR56 orphan receptor InterPro|IPR003910
**GPR56 ;GPR64 ;GPR97 ;GPR110 ;GPR111 ;GPR112 ;GPR113 ;GPR114 ;GPR115 ;GPR123 ;GPR125 ;GPR126 ;GPR128 ;GPR133 ;GPR144 ;GPR157
*Latrophilin receptor InterPro|IPR003924
**ELTD1 ;LPHN1 ;LPHN2 ;LPHN3 Subfamily B3
Subfamily B3 includes
Methuselah and otherDrosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.*
Diuretic hormone receptor InterPro|IPR002001Unclassified subfamilies
*
Ig-hepta receptor InterPro|IPR008078
**GPR116 Unclassified members
DREG ;HCTR-5 ;HCTR-6 ;KPG_003 ;KPG_006 ;KPG_008 ;KPG_009 ;RESDA1 References
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