Prostaglandin E2 receptor

Prostaglandin E2 receptor

Prostaglandin E2 receptor (53kDa), also known as PTGER2, subtype EP2 or Prostaglandin E receptor 2, is a prostaglandin receptor for prostaglandin E2. It also denotes the human gene encoding the receptor.cite web | title = Entrez Gene: PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5732| accessdate = ]

Mechanism

The receptor is a G-protein coupled receptor, which activates the G protein Gs. [ [https://catalog.invitrogen.com/index.cfm?fuseaction=viewCatalog.viewProductDetails&productDescription=37325 Invitrogen Online Ordering: Prostanoid Receptor PTGER2 Assays] ] .

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ee also

* Eicosanoid receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Duncan AM, Anderson LL, Funk CD, "et al." |title=Chromosomal localization of the human prostanoid receptor gene family. |journal=Genomics |volume=25 |issue= 3 |pages= 740–2 |year= 1995 |pmid= 7759114 |doi=
*cite journal | author=Regan JW, Bailey TJ, Pepperl DJ, "et al." |title=Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. |journal=Mol. Pharmacol. |volume=46 |issue= 2 |pages= 213–20 |year= 1994 |pmid= 8078484 |doi=
*cite journal | author=Bastien L, Sawyer N, Grygorczyk R, "et al." |title=Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11873–7 |year= 1994 |pmid= 8163486 |doi=
*cite journal | author=An S, Yang J, Xia M, Goetzl EJ |title=Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 1 |pages= 263–70 |year= 1994 |pmid= 8250933 |doi=
*cite journal | author=Stillman BA, Breyer MD, Breyer RM |title=Importance of the extracellular domain for prostaglandin EP(2) receptor function. |journal=Mol. Pharmacol. |volume=56 |issue= 3 |pages= 545–51 |year= 1999 |pmid= 10462542 |doi=
*cite journal | author=Smock SL, Pan LC, Castleberry TA, "et al." |title=Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype. |journal=Gene |volume=237 |issue= 2 |pages= 393–402 |year= 1999 |pmid= 10521663 |doi=
*cite journal | author=Desai S, April H, Nwaneshiudu C, Ashby B |title=Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration. |journal=Mol. Pharmacol. |volume=58 |issue= 6 |pages= 1279–86 |year= 2001 |pmid= 11093764 |doi=
*cite journal | author=Duckworth N, Marshall K, Clayton JK |title=An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women. |journal=J. Endocrinol. |volume=172 |issue= 2 |pages= 263–9 |year= 2002 |pmid= 11834444 |doi=
*cite journal | author=Kyveris A, Maruscak E, Senchyna M |title=Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR. |journal=Mol. Vis. |volume=8 |issue= |pages= 51–8 |year= 2002 |pmid= 11951086 |doi=
*cite journal | author=Takafuji VA, Evans A, Lynch KR, Roche JK |title=PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=66 |issue= 1 |pages= 71–81 |year= 2003 |pmid= 12051958 |doi= 10.1054/plef.2001.0299
*cite journal | author=Scandella E, Men Y, Gillessen S, "et al." |title=Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. |journal=Blood |volume=100 |issue= 4 |pages= 1354–61 |year= 2002 |pmid= 12149218 |doi= 10.1182/blood-2001-11-0017
*cite journal | author=Okuyama T, Ishihara S, Sato H, "et al." |title=Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines. |journal=J. Lab. Clin. Med. |volume=140 |issue= 2 |pages= 92–102 |year= 2002 |pmid= 12228765 |doi=
*cite journal | author=Konger RL, Scott GA, Landt Y, "et al." |title=Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression. |journal=Am. J. Pathol. |volume=161 |issue= 6 |pages= 2065–78 |year= 2003 |pmid= 12466123 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Abulencia JP, Gaspard R, Healy ZR, "et al." |title=Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28388–94 |year= 2003 |pmid= 12743126 |doi= 10.1074/jbc.M301378200
*cite journal | author=Richards JA, Brueggemeier RW |title=Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2810–6 |year= 2003 |pmid= 12788892 |doi=
*cite journal | author=Sun HS, Hsiao KY, Hsu CC, "et al." |title=Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor. |journal=Endocrinology |volume=144 |issue= 9 |pages= 3934–42 |year= 2003 |pmid= 12933667 |doi=
*cite journal | author=Bradbury DA, Newton R, Zhu YM, "et al." |title=Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49954–64 |year= 2004 |pmid= 14517215 |doi= 10.1074/jbc.M307964200
*cite journal | author=Moreland RB, Kim N, Nehra A, "et al." |title=Functional prostaglandin E (EP) receptors in human penile corpus cavernosum. |journal=Int. J. Impot. Res. |volume=15 |issue= 5 |pages= 362–8 |year= 2004 |pmid= 14562138 |doi= 10.1038/sj.ijir.3901042
*cite journal | author=Sugimoto Y, Nakato T, Kita A, "et al." |title=A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11016–26 |year= 2004 |pmid= 14699136 |doi= 10.1074/jbc.M307404200

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