Formins

Formins

Formins (formin homology proteins) are a group of proteins that are involved in the polymerisation of actin and associate with the fast-growing end (barbed end) of actin filaments [cite journal | author= Evangelista Marie, Zigmond Sally and Boone Charles | title=Formins: signaling effectors for assembly and polarization of actin filaments | journal= J Cell Sci. | year=2003 |month=July| pages=2603–11 | volume=116 | issue=Pt 13 | pmid=12775772 | doi=10.1242/jcs.00611] . The structure of formins is mainly conserved in the C-terminal Formin Homology (FH) domains namely FH1, FH2 and the more loosely defined FH3 domain [cite journal | author= Wallar Bradley J and Alberts Arthur S | title=The formins: active scaffolds that remodel the cytoskeleton | journal= Trends Cell Biol. | year=2003 |month=August| pages=435–46 | volume=13 | issue=8 | pmid=12888296 | doi=10.1016/S0962-8924(03)00153-3] . The actin nucleation-promoting activity of "S. cerevisiae" formins has been localized to the FH1-FH2 domains. Other commonly shared domains are a GTPase binding domain (GBD) that bind for example Cdc42 at the N-terminus, and a DAD or Dia-autoregulatory domain, toward the C-terminus.

References




Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • formins — A set of protein isoforms encoded by alternatively spliced ld locus of the mouse. Mutations in ld lead to disruption in pattern formation, small size, fusion of distal bones and digits of limbs and renal aplasia …   Dictionary of molecular biology

  • Microfilament — Actin cytoskeleton of mouse embryo fibroblasts, stained with Fluorescein isothiocyanate phalloidin Microfilaments ( or actin filaments) are the thinnest filaments of the cytoskeleton, a structure found in the cytoplasm of all eukaryotic cells.… …   Wikipedia

  • Forminas — Saltar a navegación, búsqueda Proteína con un dominio de homología a formina tipo 2 (FH2). Las forminas o proteínas con homología a formina son un grupo de proteínas de unión a actina que están involucradas en la inducción de la polimerización de …   Wikipedia Español

  • Actin-binding protein — Actin binding proteins (also known as ABP) are proteins that bind to actin. This may mean ability to bind actin monomers, or polymers, or both.Many actin binding proteins, including α actinin, β spectrin, dystrophin, utrophin and fimbrin, do this …   Wikipedia

  • Eurovision Song Contest 2004 (compilation) — Infobox Album | Name = Eurovision Song Contest Istanbul 2004 Type = Compilation album Artist = Eurovision Song Contest Released = May 2 2005 Recorded = Genre = Various Length = 54:03 ( Disc 1 ) 54:18 ( Disc 2 ) Label = EMI/CMC Producer = Review …   Wikipedia

  • Septins — are evolutionary conserved proteins with essential functions in cytokinesis, and more subtle roles throughout the cell cycle. Much of our knowledge about septins originates from studies of budding yeast Saccharomyces cerevisiae, where they form a …   Wikipedia

  • DIAPH1 — Diaphanous homolog 1 (Drosophila) PDB rendering based on 1v9d …   Wikipedia

  • OGAE Second Chance Contest 2003 — Host broadcaster OGAE Spain Venue Las Palmas de Gran Canaria, Spain Winning song …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”