Sympatholytic

Sympatholytic

A sympatholytic drug is a medication which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).cite web |url=http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/eight/000103503.htm |title=Dorlands Medical Dictionary:sympatholytic |format= |work= |accessdate=] Though some are indicated for various functions, they can all be used as antihypertensives.

Antiadrenergic

Antiadrenergic agents inhibit the signals of epinephrine and norepinephrine. They are primarily adrenergic antagonists, inhibiting adrenergic receptors, but there are exceptions: clonidine is an adrenergic agonist on the α2 receptor, since this receptor is located presynaptically to inhibit further release of adrenaline and noradrenaline.

Other ways of inhibiting adrenergic signaling is by catecholamine synthesis blocking, e.g. by methyltyrosine. Reserpine works by inhibiting transport into synaptic vesicles of noradrenaline by inhibiting the VMAT transporter.

In hypertension

Many antiadrenergic agents used as antihypertensives include:
*centrally acting:
**Clonidine (α2 agonist)
**Guanfacine (α2 agonist)
**Methyldopa (α2 agonist)
**Moxonidine (imidazoline receptor agonist)
**Rescinnamine (ACE inhibitor)
**Reserpine (VMAT inhibitor)
**Rilmenidine (imidazoline receptor agonist)
*ganglion-blocking
**Mecamylamine (α3β4 nicotinic receptor inhibitor)
**Trimethaphan (ganglion type receptor inhibitor)
*peripherally acting
**Prazosin (α1 antagonist)
**Guanethidine (Magnesium-ATPase inhibitor)
**Indoramin (α1 antagonist)
**Doxazosin (alpha blocker)

References

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • sympatholytic — [sim΄pə thō lit′ik] adj. [< SYMPATH(ETIC) + O + LYTIC] having the effect of decreasing the activity of the sympathetic nervous system: said of certain drugs, chemicals, etc …   English World dictionary

  • sympatholytic — Denoting antagonism to or inhibition of adrenergic nerve activity. SEE ALSO: adrenergic blocking agent, antiadrenergic. [sympatho + G. lysis, a loosening] * * * sym·pa·tho·lyt·ic .sim pə thō lit ik adj …   Medical dictionary

  • sympatholytic — adjective Etymology: International Scientific Vocabulary Date: 1943 tending to oppose the physiological results of sympathetic nervous activity or of sympathomimetic drugs < a sympatholytic agent > • sympatholytic noun …   New Collegiate Dictionary

  • sympatholytic — adj. opposing the effects of the sympathetic nervous system. Guanethidine blocks the transmission of impulses along adrenergic nerves; it is used to treat high blood pressure. Alpha blockers and beta blockers are other kinds of sympatholytic… …   The new mediacal dictionary

  • sympatholytic — sym•pa•tho•lyt•ic [[t]ˌsɪm pə θoʊˈlɪt ɪk[/t]] adj. 1) phl opposing the effects of stimulation of the sympathetic nervous system 2) a sympatholytic drug or agent • Etymology: 1940–45; sympath (etic) + o + lytic …   From formal English to slang

  • sympatholytic — I. |simpəthō|lid.ik adjective Etymology: International Scientific Vocabulary sympatho + lytic : tending to oppose the physiological results of sympathetic nervous activity or of sympathomimetic drugs used chiefly of chemical substances and their… …   Useful english dictionary

  • sympatholytic — /sim peuh thoh lit ik/, adj. Physiol., Pharm. opposing the effects of stimulation of the sympathetic nervous system. Cf. cholinolytic. [1940 45; SYMPATH(ETIC) + O + LYTIC] * * * …   Universalium

  • sympatholytic — 1. adjective That opposes the stimulation of the sympathetic nervous system 2. noun Any medicine having this effect …   Wiktionary

  • sympatholytic — sym·pa·tho·lyt·ic …   English syllables

  • Средство Симпатолитическое (Sympatholytic) — лекарственное вещество, по своему действию противоположное действию симпатической нервной системы. Гуанетидин и метилдофа блокируют передачу импульсов по адренергическим нервам; эти лекарственные вещества применяются для снижения повышенного… …   Медицинские термины

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”