Pardis Sabeti

Pardis Sabeti

Pardis C. Sabeti (born December 25, 1975) is an Iranian-American evolutionary geneticist, who developed a statistical method which identifies sections of the genome that have been subject to natural selection.cite web
url = http://www.sciencespectrumonline.com/artman/publish/article_24.shtml
title = One-on-One with Pardis Sabeti
accessdate = 2007-07-27
last = Deen
first = Lango
date = 2005-07-25
work = Science Spectrum Online
] cite web
url = http://www.cnn.com/2007/LIVING/wayoflife/07/13/genius.scientists/index.html?eref=rss_tech
title = Geniuses who will change your life
accessdate = 2007-07-27
last = Furman
first = Eric
work = CNN.com
] [cite web
last = Sabeti et al.
title = Genome-wide detection and characterization of positive selection in human populations
publisher=Nature
url = http://www.nature.com/nature/journal/v449/n7164/full/nature06250.html
date = 2007-10-18
accessdate = 2007-12-25
] Sabeti is an Assistant Professor in the Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard University. cite web
url = http://sysbio.harvard.edu/csb/research/sabeti.html
title = FAS Center for Systems Biology, Harvard University
] [http://www.telegraph.co.uk/news/uknews/1567544/Top-100-living-geniuses.html She is rated 49th in Telegraph's world's Top 100 living geniuses.]

Biography

Sabeti completed her undergraduate degree at MIT and continued her education at Oxford as a Rhodes Scholar, before returning to earn her medical degree from Harvard Medical School where she was only the third woman ever to graduate summa cum laude.cite web
url = http://www.broad.mit.edu/cgi-bin/news/display_news.cgi?id=1641
title = Broad scientist Pardis Sabeti receives prestigious research awards
accessdate = 2007-10-12
last = Davis
first = Nicole
date = 2006-06-14
] She has also received a Burroughs Wellcome Fund Career Award in the Biomedical Sciences.

Research

Sabeti addressed the problem of telling whether a mutation is due to natural selection or just random. When humans are exposed to diseases, like malaria and Lassa fever, they evolve traits that resist those diseases, such as sickle cell trait. Biologists can tell from comparing DNA sequences in populations whether mutations were due to natural selection, but those methods wouldn't work for evolutionary changes during the last 10,000 years, when diseases like malaria arose.

Sabeti took advantage of the fact that genes on the same place in the chromosome are inherited together. If a particular variation is subject to natural selection, its frequency will increase, along with the frequency of genes that have hitchhiked along with it. She developed a test that would use this principle to tell whether recent changes were due to natural selection or just chance. She applied this test to malaria variants, and saw a "whopping signal" of positive selection. This research was published in Nature. She later identified 2 genes, LARGE and DMD, that protect against Lassa fever, and show strong signals of natural selection in West Africans. [Profile: Pardis Sabeti; Picking up evolution's beat, Michael Balter, Science, 25 April 2008]

References

External links

* [http://www.pbs.org/wgbh/nova/sciencenow/0302/04.html “Profile: Pardis Sabeti” on "NOVA: Science Now", 2008 June]
* [http://network.nature.com/boston/news/Profile/2007/07/31/science-meets-mtv Science meets MTV: Broad Institute geneticist and rock singer Pardis Sabeti merges lab culture with pop culture (Nature Network Boston, 2007 July 31)]
* [http://flickr.com/photos/ahibadi/sets/72157605798942179 Thousand Days Photos (2007 May 10)]
* [http://focus.hms.harvard.edu/2005/Nov11_2005/population_genetics.shtml Genetic Road Map Drawn for Tracing Route To Common Diseases]


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Pardis Sabeti — durant le Forum économique mondial de 2008 Naissance 25 décembre 1975 Téhéran (Iran) Champs Géné …   Wikipédia en Français

  • Pardis — See Pardis Sabeti, the Harvard geneticist Pardis is a new planned city in the Tehran Province of Iran. The new Pardis satellite city has absorbed over 9,775 inhabitants in 2001. The city has room for 200,000 residents.Technology ParkAdjacent to a …   Wikipedia

  • Biological anthropology — Biological anthropology, or physical anthropology is a branch of anthropology that studies the mechanisms of biological evolution, genetic inheritance, human adaptability and variation, primatology, primate morphology, and the fossil record of… …   Wikipedia

  • List of contemporary Iranian scientists, scholars, and engineers — The following is a notable Iranian scholars, scientists and engineers around the world from the modern era. Contents: Top · 0–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z This is an incomplete list, which may never be …   Wikipedia

  • NOVA scienceNOW — opening title screen Format Science documentary Presented by Neil deGrasse Tyson …   Wikipedia

  • Bourse Rhodes — Les bourses Rhodes sont des bourses académiques créées à la suite des volontés de Cecil John Rhodes décédé en 1902. Elles permettent à ses récipiendaires d’étudier à l’université Oxford gratuitement pendant une durée de un, deux ou trois ans. La… …   Wikipédia en Français

  • Mahyad Tousi — is an Iranian American filmmaker, producer, and cinematographer. He lives in Brooklyn, New York. He is the co founder and Chief Executive Officer of BoomGen Studios, a motion picture company that focuses on entertainment content and media about… …   Wikipedia

  • Projet:Médecine/Index — Articles 0 9 1,2 dibromo 3 chloropropane · 112 (numéro d urgence européen) · 1935 en santé et médecine · 1941 en santé et médecine · 1er régiment médical · 2 iodothyronine déiodinase · 2,4,6 trichlorophénol · 2005 en santé et médecine · 2006 en… …   Wikipédia en Français

  • Selection naturelle — Sélection naturelle Les mécanismes de l évolution biologique Mécanismes non aléatoires: sélection naturelle sélection utilitaire sélection sexuelle sélection de parentèle sélection de groupe s …   Wikipédia en Français

  • Sélection naturelle — Les mécanismes de l évolution biologique Mécanismes non aléatoires : sélection naturelle sélection de survie sélection sexuelle sélection de parentèle sélection de groupe sélection s …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”