11-Hydroxy-THC

11-Hydroxy-THC

Drugbox
name = 11-hydroxy-delta-9-THC
IUPAC_name = (6"aR",10"aR")-9-(Hydroxymethyl)-6,6-dimethyl-3-pentyl- 6"a",7,8,10"a"-tetrahydro-6"H"-benzo ["c"] chromen-1-ol



width= 250
CAS_number= 36557-05-8
ATC_prefix=
ATC_suffix=
PubChem= 644022
DrugBank=
C=21 | H=30 | O=3
molecular_weight = 330.461 g/mol
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status =
routes_of_administration=

11-Hydroxy-Δ9-tetrahydrocannabinol, abbreviated as 11-OH-THC, is the main active metabolite of THC which is formed in the body after cannabis consumption.cite journal
author=Johnson JR, Jennison TA, Peat MA, Foltz RL
title=Stability of delta 9-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC in blood and plasma
journal=Journal of analytical toxicology
volume=8
issue=5
pages=202–4
year=1984
pmid=6094914
doi=
] 11-Hydroxy-THC has been shown to be active in its own rightcite journal
author=Turkanis SA, Karler R
title=Changes in neurotransmitter release at a neuromuscular junction of the lobster caused by cannabinoids
journal=Neuropharmacology
volume=27
issue=7
pages=737–42
year=1988
pmid=2901683
doi=
] , but the effects produced are not necessarily identical to those of THC.cite journal
author=Hollister LE, Gillespie HK
title=Action of delta-9-tetrahydrocannabinol. An approach to the active metabolite hypothesis
journal=Clin. Pharmacol. Ther.
volume=18
issue=06
pages=714–9
year=1975
pmid=1204277
doi=
] This might partially explain the biphasic effects of cannabis, whereby some effects such as increased appetite tend to be delayed rather than occurring immediately when the drug is consumed. [Lemberger L, Martz R, Rodda B, Forney R, Rowe H. Comparative pharmacology of Delta9-tetrahydrocannabinol and its metabolite, 11-OH-Delta9-tetrahydrocannabinol. "Journal of Clinical Investigation". 1973 Oct;52(10):2411-7. PMID 4729039]

11-Hydroxy-THC is subsequently metabolised further to 11-nor-9-carboxy-THC, which is not psychoactive but might still play a role in the analgesic and anti-inflammatory effects of cannabis.

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • THC-Carbonsäure — Strukturformel Allgemeines Name Tetrahydrocannabinol Andere Namen (−) Δ9 trans Tetrahydrocannabi …   Deutsch Wikipedia

  • 11-hydroxy-delta-9-THC — 11 Hydroxy THC (11 OH THC) Général Nom IUPAC (6aR,10aR) 9 (hydroxymethyl) 6,6 dimethyl 3 pentyl 6a,7,8,10a tetrahydrobenzo[c]chromen 1 ol …   Wikipédia en Français

  • 11-nor-9-Carboxy-THC — Drugbox IUPAC name = 1 hydroxy 6,6 dimethyl 3 pentyl 6a,7,8,10a tetrahydrobenzo [c] chromene 9 carboxylic acid width= 250 CAS number= 64280 14 4 ATC prefix= ATC suffix= PubChem= 107885 DrugBank= C=21 | H=28 | O=4 molecular weight = 344.445 g/mol… …   Wikipedia

  • Tetrahydrocannabinol — THC redirects here. For other uses, see THC (disambiguation). Tetrahydrocannabinol (THC) …   Wikipedia

  • Delta-9-Tetrahydrocannabinol — Strukturformel Allgemeines Name Tetrahydrocannabinol Andere Namen (−) Δ9 trans Tetrahydrocannabin …   Deutsch Wikipedia

  • Tetrahydrocannabinol — Strukturformel Allgemeines Name Tetrahydrocannabinol Andere Namen …   Deutsch Wikipedia

  • Tetrahydrocannabinole — Strukturformel Allgemeines Name Tetrahydrocannabinol Andere Namen (−) Δ9 trans Tetrahydrocannabi …   Deutsch Wikipedia

  • Tetrahydrocannabinolsäure — Strukturformel Allgemeines Name Tetrahydrocannabinol Andere Namen (−) Δ9 trans Tetrahydrocannabi …   Deutsch Wikipedia

  • Effects of cannabis — Short term effects of cannabis Classification and external resources ICD 10 F12.0 The effects of cannabis are caused by cannabinoids, most notably tetrahydrocannabinol (THC). Cannabis has both psychological and physiological effects on the human… …   Wikipedia

  • Cannabis — This article is about the plant genus. For use as a psychoactive drug in the genus, see Cannabis (drug). Cannabis …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”