Steroid sulfatase

Steroid sulfatase
Steroid sulfatase (microsomal), isozyme S

PDB rendering based on 1p49.
Identifiers
Symbols STS; ARSC; ARSC1; ASC; ES; SSDD; XLI
External IDs OMIM300747 HomoloGene47918 GeneCards: STS Gene
EC number 3.1.6.2
RNA expression pattern
PBB GE STS 203767 s at tn.png
PBB GE STS 203768 s at tn.png
PBB GE STS 203769 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 412 n/a
Ensembl ENSG00000101846 n/a
UniProt P08842 n/a
RefSeq (mRNA) NM_000351 n/a
RefSeq (protein) NP_000342 n/a
Location (UCSC) Chr X:
7.14 – 7.27 Mb
n/a
PubMed search [1] n/a

Steroid sulfatase (or steryl-sulfatase), formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids. It is encoded by the STS gene.[1]

Contents

Function

The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer.[1]

Clinical significance

A deficiency is associated with X-linked ichthyosis, a scaly-skin disease affecting roughly 1 in every 2,000-6,000 males.[2][3]

See also

References

Further reading

External links

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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