Chloroxylenol

Chloroxylenol
Chloroxylenol
Identifiers
CAS number 88-04-0 YesY
PubChem 2723
ChemSpider 21106017 YesY
UNII 0F32U78V2Q YesY
EC number 201-793-8
KEGG D03473 YesY
MeSH chloroxylenol
ChEMBL CHEMBL398440 N
RTECS number ZE6850000
ATC code D08AE05
Beilstein Reference 1862539
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C8H9ClO
Molar mass 156.61 g mol−1
Exact mass 156.034192617 g mol-1
Melting point

114-116 °C, 387-389 K, 237-241 °F

log P 3.377
Acidity (pKa) 9.76
Basicity (pKb) 4.24
Hazards
GHS pictograms The exclamation-mark pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
GHS signal word WARNING
GHS hazard statements H302, H315, H317, H319
GHS precautionary statements P280, P305+351+338
EU Index 604-038-00-4
EU classification Harmful Xn
R-phrases R22, R36/38, R43
S-phrases (S2), S24, S37
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Chloroxylenol (4-chloro-3,5-dimethylphenol) is an antimicrobial chemical compound used to control bacteria, algae, and fungi in adhesives, emulsions, paints, and wash tanks.[2] It is also commonly used in antibacterial soaps such as Dettol and ointments, such as the now discontinued Medicated Vaseline.[3] Studies have shown a low anti microbial activity which is enhanced by additives. Its antibacterial action is due to disruption of cell membrane potentials.[4]

Chloroxylenol is not significantly toxic to humans and other mammals, is practically non-toxic to birds, moderately toxic to freshwater invertebrates and highly toxic to fish.[2] It is a mild skin irritant and may trigger allergic reactions in some individuals. Cross sensitivity with chlorocresol is common.[3]

References

  1. ^ "chloroxylenol - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification and Related Records. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2723&loc=ec_rcs. Retrieved 7 October 2011. 
  2. ^ a b http://www.epa.gov/oppsrrd1/REDs/factsheets/3045fact.pdf
  3. ^ a b Ascenzi, Joseph M. (1996). "Chloroxylenol: an old-new antimicrobial". Handbook of disinfectants and antiseptics. New York: M. Dekker. ISBN 9780824795245. http://books.google.com/?id=tFPW4D70BmgC&pg=PA265. 
  4. ^ Aly, R; Malbach, H (1988). "Comparative antibacterial efficacy of a 2-minute surgical scrub with chlorhexidine gluconate, povidone-iodine, and chloroxylenol sponge-brushes". American Journal of Infection Control 16 (4): 173–7. doi:10.1016/0196-6553(88)90029-6. PMID 3189943. 

External links


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  • chloroxylenol — noun A compound with the chemical formula CHClO, commonly used in antibacterial soaps and toxic to fish …   Wiktionary

  • chloroxylenol — chlo·ro·xy·le·nol .klōr ō zī lə .nȯl, .klȯr , .nōl n any of several chlorine derivatives of the xylenols esp the para derivative C8H9ClO used as an antiseptic and germicide * * * chlo·ro·xy·le·nol (klor″o ziґlə nol) an antibacterial… …   Medical dictionary

  • chloroxylenol — chlo·ro·xylenol …   English syllables

  • chloroxylenol — | ̷ ̷ ̷ ̷ at chloro + noun ( s) Etymology: chlor + xylenol : any of several chlorine derivatives of the xylenols; especially : the para derivative Cl(CH3)2C6H2OH obtained as colorless crystals by chlorination …   Useful english dictionary

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  • ХЛОРОКСИЛЕНОЛ — (chloroxylenol) антисептик, получаемый из фенола, но менее токсичный и более избирательный по оказываемому им действию на бактерии; применяется в основном в качестве растворов для дезинфекции кожи. Торговое название: деттол (Dettol) …   Толковый словарь по медицине

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  • Dettol — Healthy Touch Hygenic Refresh Soap (citrus fragrance) Contents 1 Controversial use …   Wikipedia

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