- MOPP (medicine)
M.O.P.P. is a medical
acronym describing the first combinationchemotherapy regimen that treatedHodgkin's disease with a high success rate. It was developed at theNational Cancer Institute in the 1960s by a team that included Vincent DeVita, Jr.. Although no longer the most effective combination, MOPP is still used after relapse or where the patient has certain allergies orlung orheart problems which prevents the use of another regimen.MOPP's name is derived from its component drugs:
:Mustargen (also known as mechlorethamine, mustine, nitrogen mustard, or MSD):Oncovin (also known as Vincristine or VCR):Procarbazine (also known as Matulane or Natulan):Prednisone (also known as Deltasone or Orasone)The treatment is usually administered in four week cycles, often for six cycles. Drugs "M" and "O" are administered
intravenous ly, while drugs "P" and "P" are pills taken orally.MOPP has been known to cause
alopecia (hair loss) and skin sensitivity (especially to sunlight). Nausea,vomit ing, and stomachache are common, as are chills, constipation, and frequent urination. Permanent sterility may also result.
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